Titlebook: Antibody Engineering; Roland Kontermann,Stefan Dübel Book 20011st edition Springer-Verlag Berlin Heidelberg 2001 Amino acid.Antigen.Cell p

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Proximity (ProxiMol) and Step-Back Selectionsnically complex and this results in difficulties in specifically selecting antibodies which bind to a given cell surface molecule without selecting for a host of unwanted specificities in parallel. The desired antigen specificity can in many cases be obtained, but only after an intensive screening p

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Selection of Human Antibody Fragments by Anti-Idiotypic Interaction compared to the background phages or the antigen is not available in a suitable form, resulting in nonspecific adherence of the phages. For this reason researchers used anti-idiotypic antibodies for the panning procedure. These were generated by immunization of rabbits with human IgG Fab (idiotype)

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Recombinant Antibodiesle, an immense number of different molecules, bearing different specificities, is required. This diversity is generated by somatic recombination and hypermutagenesis of a set of variant genes. The genetic information for this repertoire of different antibodies is stored in the B-cell pool of our lymphatic system.

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https://doi.org/10.1007/978-3-662-04605-0Amino acid; Antigen; Cell preparation; Expression; Immunologie; Polymerasekettenreaktion; Zellpreparatione