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Titlebook: Antibodies; Structure, Synthesis Andor Szentivanyi (Dean of the College of Medicine Book 1987 Plenum Press, New York 1987 aging.antibody.au

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B Cell Development in Mammalsle B cells in birds are generated in the hindgut bursa of Fabricus, mammalian B cells are generated in hemopoietic tissues along with other blood cell lineages (28,29,34). Mammalian B cells appear first in embryonic liver and then the spleen when hemopoiesis is centered in these organs (29). Later i
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Anti-Hapten Idiotype Models in Studies of Aging and Idiotype Networksh the existence of a network of idiotypes (ids) and anti-ids. The elements in this network (B cells, T cells, and serum antibodies) normally exist in a steady state. Introduction of antigen results in expansion of specific clones thereby perturbing the steady state. Subsequent shifts in the distribu
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Antibodies to Acetylcholine, Adenosine and Glucocorticoid Receptors by an Auto-Anti-Idiotypic Routeerimental form of myasthenia gravis (MG). It will be demonstrated that the disease can be induced in the rabbit by active immunization with an anti- ligand (19,20,52) and in the mouse by passive administration of hybridoma cells that secrete a monoclonal anti-idiotypic antibody specific for the bind
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Idiotypic Interactions in the Treatment of Human Diseasesdiotypic anti-idiotypic interactions in the regulation of the human immune response to antigen has been less extensively studied. In this review we will discuss data obtained from our laboratory 011 the role the idiotypic network plays in the regulation of human immunity in health and in disease sta
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