Titlebook: Anthracycline Antibiotics in Cancer Therapy; Proceedings of the I Franco M. Muggia,Charles W. Young,Stephen K. Carte Conference proceedings

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IntroductionWe are very furtunate to have the contributions of established leaders in the study of anthracycline mechanism of action who are continuing their enlightening studies. In addition, we have new and exciting voices to add to our knowledge of anthracycline actions.

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Free Radical DamageScientists have observed that a disproportionate number of natural products and synthetic products which contain quinone groups are cytotoxic both to tumors and to bacteria. From this vantage, proposals have been made that quinones are involved in a biochemically mediated reductive mechanism that plays a part in their cytotoxic action.

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ke for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics

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https://doi.org/10.1007/978-3-642-70077-4 with nucleic acids have not provided satisfactory explanations for the differences observed in the therapeutic efficiency and spectrum of action of the various compounds; even new analogs and derivatives which display differing nuclear and DNA binding properties cannot have their characteristics reconciled with their cytotoxic activity (1–5).

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Aufgaben des Zellkerns und des Plasmasrs immediately on either side of the intercalator, but rather is associated with the base pairs one removed from the intercalator. The unwinding effect of intercalation in DNA in intact cells would be expected to distort chromatin structure and could bring into play the action of topoisomerase enzymes which could relieve the distortion.

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Welche Organellen liegen im Zellplasma?ich, by reacting with intracellular macromolecules, could explain toxic effects of the drugs. Other mechanisms such as interaction with cell membranes may also contribute to the cycotoxicity of the anthracyclines (6).

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Consequences of DNA Intercalation: Protein-Associated DNA Strand Breaksrs immediately on either side of the intercalator, but rather is associated with the base pairs one removed from the intercalator. The unwinding effect of intercalation in DNA in intact cells would be expected to distort chromatin structure and could bring into play the action of topoisomerase enzymes which could relieve the distortion.

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