Titlebook: Animal Cell Technology: Challenges for the 21st Century; Proceedings of the j Kouji Ikura,Masaya Nagao,Ryuzo Sasaki Conference proceedings

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Metabolic Flux Distributions in Hybridoma Cells at Different Metabolic States much greater than in the “efficient” state. The comparative analysis of intracellular fluxes lends credence to the idea of metabolic overflow in the excessive production of the metabolic by products: lactate and ammonia

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A Kinetic Model of Macromolecular Metabolism in Batch and Fed-Batch Cultures of Hybridoma Cells Prodofspecific antibody production rate and the decline of the specific production rate of cellular macromolecules such as DNA, RNA, protein, and polysaccharide with lower specific growth rate in the fed-batch culture.