Titlebook: Alzheimer’s Disease: Lessons from Cell Biology; K. S. Kosik (Associate Professor of Neurology and Conference proceedings 1995 Springer-Ve

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A Phosphorylated Tau Species Is Transiently Present in Developing Cortical Neurons and Is Not Assocfrom the deepest cortical layers where neurons are onto-genetically the oldest. This phosphorylated tau was found in axons and dendrites of cortical neurons at all developmental stages, whereas unphosphorylated tau tended to disappear from dendrites during development. The timing of appearance of ph

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Modifications of Phosphorylated Tau Immunoreactivity Linked to Excitotoxicity in Neuronal Cultures,l 1991; Mattson et al. 1992). Glutamate is also able to produce an intracellular signal transduction into neurons leading to protein phosphorylations (Scholz and Palfrey 1991). Tau is a microtubule-associated protein which favours microtubule polymerisation and stabilisation (Kosik 1993). One of the

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Neurofilaments and Motor Neuron Disease,tion and severe skeletal muscle atrophy. These data indicate that excessive accumulation of neurofilaments can trigger selective motor neuron failure. Since such accumulation is seen both in sporadic and familial ALS, it is almost certain to be a key intermediate in the pathway of pathogenesis leadi

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Amyloid ,-Peptide Induces Necrotic Cell Death in PC12 Cells,t of oxidative stress (Behl et al. 1992), although the two may be linked. The cytotoxicity of A.P 1–40 has been associated with a fragment including residues 25–35 (Yankner et al. 1990). This study aimed at determining the mechanism of this .25–35 induced cytotoxicity and distinguishing between eith

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,Linking Amyloid Precursor Protein Processing and Tau-Related Pathology in Alzheimer’s Disease,se amyloid, can be unremarkable, and neurofibrillary tangles often occur at sites anatomically distant from plaques..We have found that a secreted fragment of APP can stimulate the mitogen-activated protein kinase (MAPK) in a ras-dependent manner and that stimulation along this pathway results in th

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Research and Perspectives in Alzheimer‘s Diseasehttp://image.papertrans.cn/a/image/154273.jpg

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Alzheimer’s Disease: Lessons from Cell Biology978-3-642-79423-0Series ISSN 0945-6066 Series E-ISSN 2196-310X