Titlebook: Advances in Research on Neurodegeneration; P. Riederer,D. B. Calne,M. B. H. Youdim Conference proceedings 2000 Springer-Verlag Wien 2000 A

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archenemy

The molecular mechanism of dopamine-induced apoptosis: identification and characterization of genes The current major hypothesis suggests that nigral neuronal death in PD is due to excessive oxidative stress generated by auto-and enzymatic oxidation of the endogenous neurotransmitter dopamine (DA), the formation of neuromelanin and presence of high concentrations of iron.

道学气

,Monitoring neuroprotection and restorative therapies in Parkinson’s disease with PET, PET findings in transplantation trials involving implantation of human and procine fetal mesencephalic tissue is presented. It is concluded that functional imaging provides a valuable adjunct to clinical assessment when judging the efficacy of neuroprotective and restorative approaches to PD.

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举止粗野的人

Homocysteine and alcoholism,hermore, it has been found that homocysteine induces neuronal cell damage bytimulating NMDA receptors as well as by producing free radicals. Homocysteine neurotoxicity via overstimulation of N- ethyl-D-aspartate receptors may contribute to the pathogenesis of both brain shrinkage and withdrawal seizures linked to alcoholism.

synovium

Computational Methods in Applied Sciences. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.

GLUE

The ,-DOPA story revisited. Further surprises to be expected?,cific neurochemical deficits in defined brain regions were identified, and thus for which a rational, chemical therapy could be developed, ushering in the era of clinical neurochemistry. The contributions of Birkmayer and Hornykiewicz (Vienna), Barbeau and Sourkes (Montreal) and of Cotzias (New York

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