Titlebook: Advances in Research on Neurodegeneration; P. Riederer,D. B. Calne,M. B. H. Youdim Conference proceedings 2000 Springer-Verlag Wien 2000 A

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Advances in Research on Neurodegeneration978-3-7091-6301-6Series ISSN 0303-6995

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0303-6995 Overview: 978-3-211-83537-1978-3-7091-6301-6Series ISSN 0303-6995

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Narrative

Gerontology

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Hamper

宽容

,GDF-15/MIC-1 a novel member of the TGF-ß superfamily,. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.

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Margaret A. Ryan,Abhijit V. Shevade The current major hypothesis suggests that nigral neuronal death in PD is due to excessive oxidative stress generated by auto-and enzymatic oxidation of the endogenous neurotransmitter dopamine (DA), the formation of neuromelanin and presence of high concentrations of iron.