Guffaw 发表于 2025-3-21 18:53:59

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Glucose 发表于 2025-3-21 23:22:30

Methods in Molecular Biologyhttp://image.papertrans.cn/d/image/241990.jpg

myelography 发表于 2025-3-22 01:14:36

Studies in Systems, Decision and Controlbeyond the traditional “Rule-of-5” chemistry space (Lipinski et al., Adv Drug Deliv Rev. 23(1): 3–25, 1997). An important component of meeting this challenge is to design cyclic peptides with good intestinal permeability. Here we discuss the design principles for intestinal permeability that have be

Altitude 发表于 2025-3-22 05:30:05

https://doi.org/10.1007/978-3-030-21927-7leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). Although they are attractive candidates for lead discovery owing to the unique conformational features, their peptidic backbone is susceptible to proteolytic cleavage in various biological fluids that compromise t

阻挡 发表于 2025-3-22 10:18:18

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Offensive 发表于 2025-3-22 15:43:32

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Offensive 发表于 2025-3-22 20:32:43

AC Microgrid Seamless Transitionorated into cyclic peptides (CPs), many primary peptide structures and functions are markedly altered by cyclization. Accordingly, to mimic linear peptide interfaces with cyclic peptides, it can be beneficial to screen combinatorial cyclic peptide libraries. Computational methods have been developed

角斗士 发表于 2025-3-22 21:19:09

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Hay-Fever 发表于 2025-3-23 01:41:16

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浪费物质 发表于 2025-3-23 07:27:38

https://doi.org/10.1007/978-3-319-45735-2se of copper-catalyzed azide–alkyne cycloaddition (CuAAC), better known as “click reaction” in the design and synthesis of cyclic peptide and cyclic peptidomimetic compounds. The usage of “click chemistry” reactions includes various topics: (a) mimicking peptide bonds; (b) synthesis of order
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查看完整版本: Titlebook: Cyclic Peptide Design; Gilles Goetz Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug design.Small molecul