HAUNT 发表于 2025-3-23 11:26:10
https://doi.org/10.1007/978-3-319-45735-2tructural features that potentially modulate cellular permeability. Examples range from exclusively peptidic structures like cyclosporin A or phepropeptins to compounds with mostly non-peptidic character, such as telomestatin or largazole. Furthermore, semisynthetic approaches and synthesis platform熔岩 发表于 2025-3-23 15:49:44
https://doi.org/10.1007/978-3-319-21623-2 a result, the majority of existing drugs address only a narrow range of biological targets. In the era of post-genomics, transcriptomics, and proteomics, there is an increasing interest on larger modulators of proteins that can span larger surfaces, access new therapeutic mechanisms of action, andpulmonary 发表于 2025-3-23 19:01:33
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DNA-Encoded Macrocyclic Peptide Library,a macrocyclic DNA-encoded library; how to perform selection, sequencing, and data analysis to identify potential active peptides; and how to synthesize off-DNA peptides to confirm activity. This approach provides an effective tool for pharmaceutical research based on peptides.慢慢啃 发表于 2025-3-25 01:56:07
https://doi.org/10.1007/978-1-4939-9504-2Drug design; Small molecules; Natural product chemistry; Helical peptides; Cell permeability; Protein-pro