抚育 发表于 2025-3-26 22:27:35
,Building upon Nature’s Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties scaffolds associated with natural products. Here we describe recent efforts toward identification of novel natural cyclopeptides and macrocycles as well as selected medicinal chemistry strategies to increase drug-like properties or further exploration of their activity.GUILT 发表于 2025-3-27 04:55:47
Design of Oxytocin Analogs, the market for the treatment of postpartum hemorrhage. Many other OT analogs with improved pharmacological properties (e.g., barusiban, Antag III) have been identified. These peptides have been tested in clinical trials and/or used as pharmacological tools. In this chapter, the modifications of thegranite 发表于 2025-3-27 08:55:09
Discovery of Functional Macrocyclic Peptides by Means of the RaPID System,the random non-standard peptide integrated discovery (RaPID) system, has in turn allowed for the simultaneous screening of trillions of macrocyclic peptides against challenging biological targets. The macrocyclization methodologies are chosen depending on the structural and functional characteristic易碎 发表于 2025-3-27 10:22:54
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