Titlebook: Voltage-Gated Calcium Channels; Gerald Werner Zamponi,Norbert Weiss Book 2022 The Editor(s) (if applicable) and The Author(s), under exclu

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The Skeletal Muscle Calcium Channelne the unique properties of Ca.1.1’s L-type calcium currents (LTCC). Whereas calcium influx through Ca.1.1 is expendable for EC coupling, it counteracts depletion of calcium stores and maintains contractile force during prolonged activation. Genetic variants of Ca.1.1 altering calcium homeostasis cause a variety of skeletal muscle diseases.

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targets in the treatment of‘epilepsy, hypertension, and painThis book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystall

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A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century, in which Ca. channels reached maximal attention among scientists and brought the many astonishing achievements described in this book. Given the broad interdisciplinarity of Ca. channel discoveries, the present history may probably appear incomplete, but certainly, the other chapters of this book will cover all possible gaps on the matter.

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Splicing and Editing to Fine-Tune Activity of High Voltage-Activated Calcium Channelsmploying heterologous expression systems and feature the extensive use of transgenic mouse models in the field, and suggest certain novel approaches that can be applied to further address the physiological consequences of these post-transcriptional modifications of HVA calcium channels.

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A Lived History of Early Calcium Channel Discoveries Over the Past Half-Century,ium channels. This chapter aims to provide an overview of the most important discoveries that helped elucidate the structure and function of calcium channels in excitable cells. While systematically reviewing the numerous works in the field, I chose to write a personal story derived from my own expe

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