| 书目名称 | Voltage-Gated Calcium Channels | | 编辑 | Gerald Werner Zamponi,Norbert Weiss | | 视频video | | | 概述 | Provides a comprehensive update on the‘state of knowledge of voltage-gated calcium channels.Examines how calcium channels are pharmacologic targets in the treatment of‘epilepsy, hypertension, and pain | | 图书封面 |  | | 描述 | This book covers the tremendous progress in the current understanding of the molecular physiology of voltage-gated calcium channels. This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics. The chapters investigate how, with the advent of high throughput genome sequencing, numerous mutations in various calcium channel genes have been identified in patients with neurological, cardiovascular, neuropsychiatric and other disorders. This is further complemented through a much larger in vivo toolkit such as knock-out and knock-in mice. The chapters further discuss the increased complexity of calcium channel physiology that arises from mRNA editing and splicing. Finally, the book also provides an overview of the updated research on calciumchannel inhibitors that can be used both in vivo and in vitro, and which may serve as a spring board for new calcium channel therapeutics for human disease. Voltage-Gated Calcium Channels is useful for aca | | 出版日期 | Book 2022 | | 关键词 | Activation; Biophysics; Peptide; cardiovascular; genes; distribution; physiology; regulation; the role of CA | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-031-08881-0 | | isbn_softcover | 978-3-031-08883-4 | | isbn_ebook | 978-3-031-08881-0 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 16:35:32
