Titlebook: Vitamin D; Physiology, Molecula Michael F. Holick Book 19991st edition Humana Press 1999 Absorption.Calcium.Metabolite.Public Health.Vitami

沙文主义

Molecular Defects in the Vitamin D Receptor Associated with Hereditary 1,25-Dihydroxyvitamin D-Resitance to vitamin D. The active form of vitamin D, 1,25-dihydroxyvitamin D. [1,25(OH).D.], elicits hormonal action through the vitamin D receptor (VDR), a member of the steroid-thyroid-retinoid family of nuclear transcription factors. In target cells the activated 1,25(OH).D.-VDR complex regulates th

体贴

Book 19991st edition each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of in

割让

Noncalcemic Actions of 1,25-Dihydroxyvitamin D3 and Clinical Implications,fficiency of intestinal calcium absorption. When dietary calcium absorption is inadequate to satisfy the body’s requirement, then 1, 25(OH).D mobilizes stem cells and induces them to become mature osteoclasts, which in turn mobilize calcium stores from bone to maintain serum calcium in a physiologically acceptable range ..

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Photobiology of Vitamin D, as well as the mobilization of calcium and phosphorus stores from bone .. In addition, 1,25(OH).D has other biologic actions in many tissues or cells that possess the 1,25(OH).D receptor, including enhancement of cellular differentiation and/or inhibition of cellular proliferation in cultured fibroblasts and keratinocytes ..

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The Vitamin D Binding Protein and Its Clinical Significance,oteins binds vitamin D sterols with high affinity, however. DBP is 122 amino acids shorter than albumin and α-fetoprotein, and the genes of all three of these proteins map to human chromosome 4g11–22 ..

Vertebra

Vitamin D Receptor Translocation,ins, such as the steroid receptors, into the nucleus is a multistep, highly regulated, time- and energy-dependent process [recently reviewed by Jans and Hubner (.)]. Protein import involves transport from the cytoplasm to the NPC, translocation through the NPC, and intranuclear targeting (Fig. 1).

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Evolution, Biologic Functions, and Recommended Dietary Allowances for Vitamin D,e and process the scarce amounts of calcium in their environment in order to maintain their calcium-dependent cellular and metabolic activities and also satisfy the large requirement for calcium to mineralize their skeletons.

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