书目名称 | Virus Variability, Epidemiology and Control | 编辑 | Edouard Kurstak,R. G. Marusyk,M. H. V. Regenmortel | 视频video | http://file.papertrans.cn/984/983518/983518.mp4 | 丛书名称 | Applied Virology Research | 图书封面 |  | 描述 | Virus Variability and Impact on Epidemiology and Control of Diseases E. Kurstak and A. Hossain I. INTRODUCTION An important number of virus infections and their epidemic developments demonstrate that ineffec tiveness of prevention measures is often due to the mutation rate and variability of viruses (Kurstak et al., 1984, 1987). The new human immunodeficiency retroviruses and old influenza viruses are only one among several examples of virus variation that prevent, or make very difficult. the production of reliable vaccines. It could be stated that the most important factor limiting the effectiveness of vaccines against virus infections is apparently virus variation. Not much is, how ever, known about the factors influencing and responsible for the dramatically diverse patterns of virus variability. II. MUTATION RATE AND VARIABILITY OF HUMAN AND ANIMAL VIRUSES Mutation is undoubtedly the primary source of variation, and several reports in the literature suggest that extreme variability of some viruses may be a consequence of an unusually high mutation rate (Holland et al., 1982; Domingo et al., 1985; Smith and Inglis, 1987). The mutation rate of a virus is defined as the probabil | 出版日期 | Book 1990 | 关键词 | Antigen; avian influenza; development; epidemiology; evolution; immunodeficiency; infection; infections; mol | 版次 | 1 | doi | https://doi.org/10.1007/978-1-4757-9271-3 | isbn_softcover | 978-1-4757-9273-7 | isbn_ebook | 978-1-4757-9271-3 | copyright | Springer Science+Business Media New York 1990 |
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