Titlebook: Virus Protein and Nucleoprotein Complexes; J. Robin Harris,David Bhella Book 2018 Springer Nature Singapore Pte Ltd. 2018 Viral Protein.Vi

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Oligomerization of Retrovirus Integrases,on is carried out by integrase (IN), a virus-encoded enzyme that forms an oligomeric ‘intasome’ complex with both ends of the linear viral DNA to catalyze their concerted insertions into the backbones of the host’s DNA. IN also forms a complex with host proteins, which guides the intasome to the hos

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,Structure and Function of the Human Respiratory Syncytial Virus M2–1 Protein,espiratory tract infection worldwide, responsible for up to 199,000 deaths each year. The only FDA-approved regime to prevent HRSV-mediated disease is pre-exposure administration of a humanized HRSV-specific monoclonal antibody, which although being effective, is not in widespread usage due to its c

CHASM

Filamentous Bacteriophage Proteins and Assembly,igms in structural molecular biology and offer insight into molecular assembly, a process that remains to be fully understood. In this chapter, an overview on filamentous bacteriophages will be provided. In particular, we review the constituent proteins of filamentous bacteriophage and discuss assem

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The Bacteriophage Head-to-Tail Interface,of the viral genetic information to the host cell at the beginning of infection. In tailed bacteriophages, the portal system is connected to a tail device that delivers their genome to the bacterial cytoplasm. The head-to-tail interface is a multiprotein complex that locks the viral DNA inside the p

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Beyond Channel Activity: Protein-Protein Interactions Involving Viroporins,ers, disrupting the physiology of the host to the advantage of the virus. Consequently, efforts during the last few decades have been focused towards the discovery of viroporin channel inhibitors, but in general these have not been successful to produce licensed drugs. Viroporins are also involved i

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Protein Complexes and Virus-Like Particle Technology,at controlled conditions. Therefore, the basic knowledge about the mechanisms of viral particle formation is highly important for designing of industrial applications. As an alternative to genetic and chemical processes, different physical methods are frequently used for VLP construction, including

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The Role of Flaviviral Proteins in the Induction of Innate Immunity,Zika virus, West Nile virus, Japanese encephalitis virus, and Dengue virus have the potential to cause severe disease. Extensive studies have been performed to elucidate the structure and replication strategies of flaviviruses, and current studies are aiming to unravel the complex molecular interact

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0306-0225 and function.Written by acknowledged experts in their field..The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers nume