Titlebook: Virology and Immunology in Multiple Sclerosis: Rationale for Therapy; Proceedings of the I Carlo L. Cazzullo,Domenico Caputo,Mauro Zaffaron

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Inexorable

Intrathecal IgG Synthesis in Multiple Sclerosis: Correlation with Clinical Parametersed by several authors (review in [41]), but the high number of interdependent and ill-defined clinical variables involved in the disease likely account for the discrepant results, which have prevented definite conclusions from being reached.

Interferons

HLA Studies in the Multiple Sclerosis Populationtrongly supports MS heredity. Indeed [7] the incidence of MS is 7 times higher in first cousins, 12 times higher in parents, 22 times higher in brothers, 259 times higher in heterozygotes, and 535 times higher in monozygote twins. According to racial criteria, Caucasians are more affected than colored races [1–4].

陈旧

Risk Factors, Course, and Prognosis of Multiple Selerosis, and unpredictable course. It has also been the single neurologic disorder about which the most has been written, and in this regard epidemiology has contributed its share. There is then some information available for this disease as to risk factors, the course of the illness, and factors predictive of this course.

遗弃

Different T-Cell Response to Myelin Basic Protein in Multiple Sclerosis Patients and in Healthy Subjlity and/or sensitivity of the assays. We present here some data suggesting that T-cell response to BP is quantitatively and qualitatively different in MS patients from that seen in healthy subjects [3, 4].

encyclopedia

Multiple Sclerosis: Phenotypic Immunogenetic Markers and Nucleic Acid Biochemistryt confer susceptibility to MS. The next step should be to sequence the susceptibility genes, to delineate their gene products — i.e., to identify the molecules that are involved in the pathogenesis — to studv their function, and — ultimately — to provide a molecular basis for therapy.

painkillers

Genetics in Multiple Sclerosis — with Special Emphasis on Twin Studieselian mode of inheritance is ruled out. The discovery of an association of MS with the genetic HLA system suggests the importance of genetic factors for the development of MS. This association suggests that MS may occur only in persons with a susceptible genotype.

Decibel

欢腾

Studies of the Natural History of Multiple Sclerosiss of outcome (see below). This finding has great implications for selection of patients and endpoints considered in clinical trials. While concurrent controls are essential in therapeutic trials, these and other considerations demonstrate the need for natural history information.

ALOFT

Space-Time Aggregation in a Small Village in Italy: Buti (Pisa)rs [1–3]. On the other hand, different aggregations in space and in time have been pointed out for patients affected by MS. In Table 1 the most important among these aggregations and the suggested correlations are listed. One investigation has hypothesized that one or two different