Titlebook: Viral Proteins Counteracting Host Defenses; Ulrich H. Koszinowski,Hartmut Hengel Book 2002 The Editor(s) (if applicable) and The Author(s)

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https://doi.org/10.1007/978-3-642-59421-2Antigen processing; Chemokine; antigen; antigen presentation; antiviral response; apoptosis; cytomegalovir

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978-3-642-63974-6The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE

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Viral Proteins Counteracting Host Defenses978-3-642-59421-2Series ISSN 0070-217X Series E-ISSN 2196-9965

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Ulrich H. Koszinowski,Hartmut HengelIncludes supplementary material:

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Human Cytomegalovirus Inhibition of Major Histocompatibility Complex Transcription and Interferon S antiviral effects of the interferons. In this review, we focus on an emerging paradigm in which the effectiveness of viruses, particularly human cytomegalovirus, to escape antiviral immune responses is significantly enhanced by their ability to inhibit MHC transcription and interferon (IFN)-stimulated (JAK/STAT) signal transduction.

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,Strategies for the Identification and Analysis of Viral Immune-Evasive Genes — Cytomegalovirus as ater reviews procedures which have been used for successful identification of immunomodulatory genes in the past and deals with recent methods which may be applicable for the identification of additional immunomodulatory functions unknown so far.

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Viral Evasion of Natural Killer Cells During Human Cytomegalovirus Infection,le played by NK cells in immune defence against HCMV and we describe potential strategies the virus has developed to escape from NK cell-mediated lysis. We focus in particular on a newly described protein, HCMV gpUL40, that induces cell surface expression of HLA-E, a non-classical class I molecule known to regulate NK cell functions.