| 书目名称 | Viral Proteins Counteracting Host Defenses |
| 编辑 | Ulrich H. Koszinowski,Hartmut Hengel |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Current Topics in Microbiology and Immunology |
| 图书封面 |  |
| 描述 | Since the first observations of viral interference with antigen presentation in the MHC class-I pathway, the field has advanced to a detailed analysis. We know numerous genes and for some of them we have profound information on their mechanistic function. The antigen presentation pathway is affected at all stages starting from proteasomal degradation of an antigenic viral protein, as shown for EBV, transfer of the proteasomal cleavage products as peptides in the ER by specific transporters, the loading of the nascent MHC class-I molecule, and finally the transport of the complex to the surface and presentation in a normal or deranged form. All these different steps of the MHC class-I antigen presentation pathway are targets for viral proteins. Not only MHC class-I but also MHC class-II proteins are a target of viral influence either by direct downregulation and degradation of proteins or by interference of signal transduction pathways. |
| 出版日期 | Book 2002 |
| 关键词 | Antigen processing; Chemokine; antigen; antigen presentation; antiviral response; apoptosis; cytomegalovir |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-642-59421-2 |
| isbn_softcover | 978-3-642-63974-6 |
| isbn_ebook | 978-3-642-59421-2Series ISSN 0070-217X Series E-ISSN 2196-9965 |
| issn_series | 0070-217X |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
发表于 2025-3-21 17:58:46
