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Titlebook: Vertebrate Motoneurons; Michael J. O‘Donovan,Mélanie Falgairolle Book 2022 Springer Nature Switzerland AG 2022 Motoneurons.Central pattern

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The Cellular Basis for the Generation of Firing Patterns in Human Motor Unitsnds. The one to one relationship between a motoneuron and its innervated muscle fibers allow motoneuron firing patterns to be readily measured in humans. In this chapter, we summarize the current understanding of the cellular basis for the generation of firing patterns in human motor units. We provi
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Motoneuron Diseasesl) motoneurons, lower (spinal) motoneurons or, often both. MNDs can occur from birth to adulthood and have a highly variable clinical presentation, even within gene-positive forms, suggesting the existence of environmental and genetic modifiers. A combination of cell autonomous and non-cell autonomo
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From Physiological Properties to Selective Vulnerability of Motor Units in Amyotrophic Lateral Sclerrther displayed in different levels of vulnerability of distinct motor units to neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). We summarize recent data suggesting that, contrary to the excitotoxicity hypothesis, the most vulnerable motor units are hypoexcitable and experienc
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Motoneuronal Regulation of Central Pattern Generator and Network Functionan modulate the frequency of fictive locomotion activated by a drug cocktail. In adult animals, motoneurons have been shown to regulate swimming in the zebrafish, and vocalization in fish and frogs. We discuss the significance of these findings and the degree to which motoneurons may be considered a part of these central pattern generators.
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Extraocular Motoneurons and Neurotrophism fiber (SIF), or the peculiar multiply innervated muscle fiber (MIF). SIF motoneurons show anatomical and physiological differences with MIF motoneurons. The latter are smaller and display lower eye position and velocity sensitivities as compared with SIF motoneurons.
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