Titlebook: Vectors as Tools for the Study of Normal and Abnormal Growth and Differentiation; Heinz Lother,Rudolf Dernick,Wolfram Ostertag Book 1989 S

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Visualization by nlsLacZ of Gene Activity During Mouse Embryogenesis,rulation. From these progenitors, many distinct cell types develop during the next few days. Their probable number is far greater than the number of described histological cell types. When the embryo progenitor cells are determined the genome has been epigenetically modified. Indeed, the male and fe

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Mutations in Transgenic Mice,r human hereditary diseases but also permits a systematic genetic dissection of the mammalian genome. In mammals, three approaches have been successful in inducing mutations (Gridley et al., 1987; Jaenisch, 1988): (i) infection of preimplantation mouse embryos with retroviruses, (ii) microinjection

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Cellular Target Sequences for Retrovirus Integration,d host cell. Although central to the retroviral life cycle and decisive for many of the biological and pathological consequences of a retrovirus infection, the molecular events involved in the integration process are only partly understood. Viral DNA synthesis by reverse transcription and the struct

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Identification of Retroviral Sequences Involved in the Inactivation of the Viral Genome in Embryona viral genome to accommodate foreign DNA sequences combined with its ability to infect a wide variety of cells make retroviruses an attractive system for gene transfer. However, the use of retroviruses to introduce and express foreign genes in mouse preimplantation embryos has been hampered because

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Strand Switching During Retroviral Reverse Transcription,genome into a linear double stranded DNA copy. A principal area of research in our lab has centered on template switching during reverse transcription and the consequences of this translocation depending on whether switching occurs intermolecularly or intramolecularly. For these studies we have exam

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Cell Targeting by Recombinant Retroviruses Using Bi-Specific Antibody Complexes,d successfully to infect human cells with ecotropic murine retroviruses via the interaction with MHC class I and class II antigens. The sequential protocol we developed requires less stringent safety constraints than would handling of amphotropic virus stocks. Although its efficiency is still relati