Titlebook: Vascular Disease and Injury; Preclinical Research Daniel I. Simon,Campbell Rogers Book 2001 Springer Science+Business Media New York 2001 S

对将来事件

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B-cell

brachial-plexus

充满人

Nonhuman Primate Models of Arterial Injury and Repairon the use of experimental animal models of vascular injury. The development and use of certain experimental models have been invaluable in the development of new pharmaceuticals in areas such as thrombosis and thrombolysis. The results generated from studies in models of restenosis have suggested t

散开

Experimental Models of Arteriovenous Graftinga formation and the accelerated rate of atherosclerosis in these grafts leads to an unacceptably high failure rate, necessitating reoperation or revision in 50% of patients within 10 yr. Other conduit systems have proven to be less reliable because of limitations in availability or higher rates of t

STALL

Wire Denudation and Ligation Models of the Mouse Carotid Arterymouse. Using genetically altered mice in these models would allow researchers to define the role of certain genes in the events associated with intimal lesion formation, remodeling, and endothelial cell growth. For the rat, the balloon catheter denudation model has become the most widely applied mod

HEPA-filter

Endothelial Denudation and Arterial Dilation in the Mousensgenic and knockout strains. However, arterial lumen size (i.e., carotid- and femoral-artery diameter <0.5 mm) precludes endovascular balloon injury as typically performed in the rat and larger animals. We have recently developed a novel form of mechanical carotid-artery dilation and complete endot

中和

食料

向外才掩饰

A Murine Model of Arterial Injury and Thrombosis genetics have enabled investigators to selectively modify the mouse genome to study the function of specific genes and proteins in vivo. In this chapter, we describe a method for studying arterial thrombosis in mice. This method exhibits several features observed in large animal thrombosis models.