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Titlebook: Validation in Chemical Measurement; Paul Bièvre,Helmut Günzler Book 2005 Springer-Verlag Berlin Heidelberg 2005 Analytical Chemistry.DIN E

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Qualification and validation of software and computer systems in laboratories, by peers, if necessary. Finally, the function and performance of the system is tested by typical anticipated users outside the development department in a real laboratory environment. All development phases including test activities and the final release follow a well-documented procedure.
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Validation criteria for developing ion-selective membrane electrodes for analysis of pharmaceuticalectrodes are more suitable for validation than the solid variety. The influence of the stability of ion pair complexes from the membrane on various parameters (e.g. response, limit of detection, and selectivity) is discussed. Validation criteria are proposed.
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Is the estimation of measurement uncertainty a viable alternative to validation?,ainty are described. The major advantages are that the estimations of measurement uncertainty are very efficient, and can be performed before analysis of the samples. The results of measurement uncertainty influence the type of analysis employed in the development process, and the measurement design can be adjusted to the need of the process.
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,Determination of hydrocarbons in water — interlaboratory method validation before routine monitorins and by setting target values for precision, the proficiency of participating laboratories could be tested as a qualifying step before involvement in PLC-4 routine monitoring. The results of the exercise indicate that hydrocarbons in water samples can be monitored as a mandatory test item within the framework of PLC-4.
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