Titlebook: V(D)J Recombination; Pierre Ferrier Book 2009 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science

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Large-Scale Chromatin Remodeling at the Immunoglobulin Heavy Chain Locus: A Paradigm for Multigene rge loci must be kept closed in lymphocytes in which they do not normally recombine, to guard against genomic instability generated by the DNA double strand breaks inherent to the V(D)J recombination process. To manage all of these demanding criteria, V(D)J recombination is regulated at numerous lev

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Genetic and Epigenetic Control of V Gene Rearrangement Frequency,ipitation (ChIP) suggests that differences in the structure of the chromatin associated with each gene is also a major factor in differential accessibility for rearrangement. Finally, transcription factors can direct accessibility for recombination, possibly by recruiting chromatin-modifying enzymes

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,Dynamic Aspects of TCRα Gene Recombination: Qualitative and Quantitative Assessments of the TCRα Ch the combinatorial diversity of the TCRα chain repertoire. The recombination profile is compatible with a sequential opening of the V region with progressive tracking along the two regions in opposite directions starting from the nearest and then moving towards the most distant V and J gene segments

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Normal and Pathological V(D)J Recombination: Contribution to the Understanding of Human Lymphoid Maf clonal evolution. Ig/TCR VDJ errors are also at the origin of recombinase mediated deregulated expression of a variety of proto-oncogenes in ALL, whereas in lymphoma it is increasingly clear that IgH containing translocations result from abnormalities other than VDJ errors (somatic hypermutation a

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ecisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to gener978-1-4939-0124-1978-1-4419-0296-2

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Iratxe Abarrategui,Michael S. Krangeligung über die dieser Arbeit gewidmeten Lebensjahre auszudriicken und den leitenden Stellen un serer vorgesetzten Behörden fiir die stete Forderung unserer Arbeit zum Wohl der Nervenkranken herzlichen Dank zu sagen.