Titlebook: Urological Oncology; Vinod H. Nargund,Derek Raghavan,Howard M. Sandler Book 2015Latest edition Springer-Verlag London 2015 surgical oncolo

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978-0-85729-481-4Springer-Verlag London 2015

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Experimental Urological Oncology: Cellular, Molecular, and Animal,n humans. The above sequentially-complex models allow the study of cancer cell and tumour biology, as well as chemopreventative, anticancer and immune therapeutics. Here, we describe the basic principles of cancer models, and give specific examples relevant to urological malignancies.

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Principles of Radiotherapy in Urologic Tumors,led to improved efficacy of radiation in controlling cancers while decreasing toxicity. Currently, radiotherapy plays a central role in the management of many genitourinary malignancies, for both definitive management of localized disease and palliation of metastatic disease.

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Experimental Urological Oncology: Cellular, Molecular, and Animal,l-derived cancer cells, immortalized by genetic manipulations, and maintained in monolayer or co-cultured with non-cancer cells in biocompatible 3-D scaffolds. Immortalized cells may be ectopically or orthotopically allo- or xeno-transplanted into animal hosts, where they establish primary tumours a

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Genetics and Genito-Urinary Cancer, networks. In normal cells these networks ensure cellular proliferation and tissue structure is tightly regulated. There are key tumour suppressor genes (TSG) and networks such as the p53 and pRB networks and protoncogenic networks such as the RAS/RAF/MAPK cascade that are commonly dysregulated in m

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