Titlebook: Uremic Toxins and Organ Failure; Hideyuki Saito,Takaaki Abe Book 2020 Springer Nature Singapore Pte Ltd. 2020 Uremic toxins.Gut microbiome

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Uremic Toxicity and Bone in CKD,ease that predisposes these patients to increase fracture risk is a serious issue. However, bone disease in CKD is a complex disorder and not completely elucidated. Uremia-related bone abnormalities, or bone fragility, have even more complicated pathological processes. We review the current literatu

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Uremic Solutes and Sarcopenia,lecular mechanisms of muscle atrophy in CKD. A persistent imbalance between protein synthesis and degradation causes a loss of muscle mass. A decrease in insulin/IGF-1-Akt-mTOR signaling and an increased ubiquitin–proteasome system have emerged as inducers of muscle loss. During muscle wasting, abno

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Book 2020ure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic i

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Overview of Uremic Toxins,mplications such as cardiovascular disease, bone disease, and sarcopenia. Mass spectrometry has been successfully applied to identify and quantify the uremic toxins in the uremic blood and tissues, and have enabled the identification of novel uremic toxins, and elucidated their role in the uremic complications.

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Hideyuki Saito,Takaaki AbeProvides detailed descriptions of toxico-pathological mechanisms.Presents the latest research on the gut-kidney axis.Describes a new therapeutic strategy for CKD.Includes special chapters in indoxyl s

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