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Titlebook: Uremic Toxins and Organ Failure; Hideyuki Saito,Takaaki Abe Book 2020 Springer Nature Singapore Pte Ltd. 2020 Uremic toxins.Gut microbiome

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发表于 2025-3-21 18:04:28 | 显示全部楼层 |阅读模式
书目名称Uremic Toxins and Organ Failure
编辑Hideyuki Saito,Takaaki Abe
视频video
概述Provides detailed descriptions of toxico-pathological mechanisms.Presents the latest research on the gut-kidney axis.Describes a new therapeutic strategy for CKD.Includes special chapters in indoxyl s
图书封面Titlebook: Uremic Toxins and Organ Failure;  Hideyuki Saito,Takaaki Abe Book 2020 Springer Nature Singapore Pte Ltd. 2020 Uremic toxins.Gut microbiome
描述This book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies for uremia and related organ failure associated with kidney injuries and diseases. Retained uremic toxins cause a variety of symptoms, such as hypertension, fatigue, renal anemia, osteoporosis and neurologic impairment, which are apparent in chronic kidney disease (CKD) patients. The human gastrointestinal tract contains trillions of microorganisms, referred to as gut microbiota, which support the host metabolism by producing nutrients, such as vitamins and short-chain fatty acids. However, they also produce various harmful uremic toxins that show renal and cardiovascular toxicity, and correlate with an increased mortality in CKD patients. The composition and balance of gut microbiota are associated with the accumulation of uremic toxins and the pathophysiology of CKD, and as such are being considered for a novel therapeutic strategy.
出版日期Book 2020
关键词Uremic toxins; Gut microbiome; Systemic disorders; CKD; Indoxyl sulfate; D-serine; Uremic solutes; Sulfotra
版次1
doihttps://doi.org/10.1007/978-981-15-7793-2
isbn_softcover978-981-15-7795-6
isbn_ebook978-981-15-7793-2
copyrightSpringer Nature Singapore Pte Ltd. 2020
The information of publication is updating

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发表于 2025-3-21 21:36:11 | 显示全部楼层
发表于 2025-3-22 03:21:50 | 显示全部楼层
D-serine as a Novel Uremic Toxin, D-amino acid metabolic abnormality, e.g., increased D-serine level in the plasma or kidney, maybe a novel causal factor of kidney damage. This chapter discusses the pathophysiological impact of D-serine in the kidney as a novel uremic toxin and compares it with other amino acid-derived waste products, such as .-cresyl sulfate or indoxyl sulfate.
发表于 2025-3-22 08:22:26 | 显示全部楼层
utic strategy for CKD.Includes special chapters in indoxyl sThis book describes the latest research on the gut-kidney axis of ureic solutes; the toxico-pathological mechanisms of uremic toxin-induced organ failure, including kidney and cardiovascular tissue; and the preventive therapeutic strategies
发表于 2025-3-22 11:29:31 | 显示全部楼层
发表于 2025-3-22 15:44:48 | 显示全部楼层
Overview of Uremic Toxins,clude small water-soluble compounds (molecular weight <500 Da), protein-bound compounds (mostly molecular weight <500 Da), and middle molecules (molecular weight ≧500 Da). Hemodialysis with a high-flux membrane can efficiently remove not only the small water-soluble compounds but also the middle mol
发表于 2025-3-22 19:04:21 | 显示全部楼层
Review: Uremic Toxins and Gut Microbiome,kidney disease (CKD), alternations of microbiome composition which promote CKD and cardiovascular disease (CVD) progression are called “dysbiosis.” In dysbiotic gut microbiota, increasement of gut-derived protein bound uremic toxins (Indoxyl sulfate .-Cresyl sulfate, phenyl sulfate) and trimethylami
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发表于 2025-3-23 05:22:20 | 显示全部楼层
Uremic Toxin-Related Systemic Disorders,ystemic disorders, such as cardiovascular disease, mineral and bone disorders, and infectious disease. The direct or indirect interaction between various uremic toxins and organ/tissues induce systemic disorders in patients with CKD, known as “uremic toxin-related systemic disorders.” Among various
发表于 2025-3-23 08:01:57 | 显示全部楼层
Uremic Toxins and Cardiovascular Disease,rdiorenal syndrome, is directly related to enhanced cardiovascular mortality and morbidity. Uremic cardiomyopathy is another characteristic cardiac pathology (reduced contracting/dilating function of the left ventricle leading to heart failure) commonly found in CKD. CKD patients are also predispose
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