Titlebook: Unusual DNA Structures; Proceedings of the F Robert D. Wells,Stephen C. Harvey Conference proceedings 1988 Springer-Verlag New York, Inc. 1

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Cruciform Transitions Assayed Using a Psoralen Crosslinking Method: Applications to measurements of developed for detecting cruciforms, including: scission of the DNA with nucleases specific for the unpaired bases at the termini of cruciform arms (Lilley, 1980, 1981; Panayotatos et al; Singleton et al,); scission with restriction enzymes (Geliert et al; Courey et al); electrophoretic resolution o

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Hyperreactivity of the B-Z Junctions Probed by Two Aromatic Chemical Carcinogens, 2-N,N-Acetoxyacet-4,6-dimethyldipyrido[1,2–:3′,2′-d] imidazole has been studied. The modification of DNA has been analysed at the nucleotide level by means of the 3′–5′ exonuclease activity of T4 DNA polymerase. Both carcinogens bind covalently to (dC-dG). and (dG-dT). sequences inserted in closed circular plasmids

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Inherently Curved DNA and its Structural Elements,1980; Trifonov, 1980). First physical observations (Marini et al, 1982) have supported the idea while recent circularization experiments (Ulanovsky et al, 1986) and electron microscopy (Griffith et al., 1986) provided direct demonstration that such curved DNA, indeed, exists. Numerous studies on the

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DNA Flexibility Under Control: The Jumna Algorithm and its Application to BZ Junctions,g the beautiful images of nucleic acid structure that we were able to create. These images had several clear advantages over molecular models: they could be created quickly, they didn’t need supports to keep them in place, they were accurate, they could be colored to reveal many interesting properti

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Base Sequence Effects in Curved and Rodlike DNA,erties of double helical DNA. The side groups introduce subtle irregularities in the local geometries of crystalline oligomers (Conner .; Dickerson & Drew 1981a; Fratini .; Kneale .; McCall . 1985, 1986; Shakked .; Viswamitra .; Wang . 1982a, 1982b) and affect the observed twisting of adjacent resid

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Biophysical Principles of Specificity and Stability of Protein-DNA Interactions: Application to RNA macromolecular concentration variables but also by the concentrations of low molecular weight competitors, especially electrolyte ions (Record and Mossing, 1987). Given this situation, how can one characterize the contributions of various noncovalent interactions to the stability and specificity of

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Immunochemical Approaches to the Definition of Unusual Nucleic Acid Structures,ibodies can detect changes associated with physiological modulation of protein structure (such as occurs on oxygenation and de-oxygenation of hemoglobin or allosteric modification of enzymes), evolutionary substitutions of amino acids, and the much larger changes associated with denaturation (review

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