Titlebook: Ultrastructure of the Connective Tissue Matrix; A. Ruggeri,P. M. Motta Book 1984 Martinus Nijhoff Publishers, Boston 1984 X-ray.biochemist

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Electron microscopy of the collagen fibril,rmation of this triple helix is a Gly-X-Y repeating tripeptide unit in the amino acid sequence of the three chains, where X and Y can be any amino acids but are often the imino acids proline and hydroxyproline. This sequence, with glycine in every third position and with an unusual abundance of hydr

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Electron microscopy of proteoglycans,connective tissues. They have also been identified as components of basement membranes and cell surface coats. Chemically, the proteoglycans consist of a protein core to which glycosaminoglycan chains are covalently attached. The latter are composed of alternating uronic acid and hexosamine residues

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Elastogenesis in embryonic and post-natal development,stood. This is, in part at least, a reflection of the persistence of uncertainties concerning the interpretation of several aspects of the conformation and supramolecular organization of elastin. It is, however, to be ascribed primarily to the difficulty of applying classical biochemical techniques

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The structural basis of calcification,ber of investigators using a variety of techniques. Despite much progress, however, most of the basic steps in the process are still uncertain. This mainly depends on the fact that calcification is not simply the coprecipitation of calcium and phosphate ions within an organic matrix, as it may seem

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Electron microscopy of the basement membranes,g to Pease (1) its presence allows the remarkable histological order and complexity of the multicellu-lar organisms. This concept clearly emerged after the introduction of the electron microscope into histological research, i.e. after the basement membranes had been unmistakably identified by a morp

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Book 1984 ll:panage of sister research techniques such as biochemistry, physiology, immunology, X-ray diffraction, etc. It is now possible to reach molecular and submolecular levels, making this technique indispensable in every type of research. Electron microscopy alone often provides enough information to

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Growth and development of collagen fibrils in connective tissue,ibres, cellular constituents, water and minerals — but they are assembled in a multitude of different ways. Ultimately, the interactions of these components with one another bestow the appropriate mechanical attributes upon the tissue.

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