Titlebook: Ubiquitin; Martin Rechsteiner Book 1988 Springer Science+Business Media New York 1988 ATP.RNA.genetics.protein.receptor.system

漂白

Ubiquitinated Histones and Chromatin, structure, but it should be stated at the outset that we do not know how this histone modification influences transcriptional or mitotic processes. We do know, however, some aspects of the structure and metabolism of histone-Ub conjugates, and these facts should provide clues to the role of Ub in chromatin dynamics.

补助

Protein Breakdown and the Heat-Shock Response,etic errors, incorporation of amino acid analogs into proteins, or postsynthetic damage to normal cell constituents. However, such polypeptides generally fail to accumulate . to the levels of normal gene products because they are rapidly degraded to amino acids.

Nonthreatening

Introduction,years ago when Gideon Goldstein and his colleagues. isolated it as a protein capable of inducing B-lymphocyte differentiation. Because the antibodies prepared against Ub reacted with similar proteins in organisms as diverse as mammals, yeast, and celery, the protein was named ubiquitous immunopoieti

剥皮

斥责

heckle

Ubiquitin Activation and Ligation,espiratory inhibitors decrease the rate of release of amino acids from cells. Therefore, these compounds, which decrease intracellular ATP concentration, inhibit intracellular protein turnover. Since peptide bond hydrolysis is a thermodynamically favorable process, why should protein break down requ

kindred

HACK

Ubiquitin Carboxyl-Terminal Hydrolases,, removal of ubiquitin from ubiquitinated histones is extensive during metaphase and during periods of altered gene expression. One may expect that Ub, which is a very old protein in evolutionary terms, may be involved in post-translational modifications of other proteins, and hydrolases, possibly w

陈列

Ubiquitinated Histones and Chromatin, known to play an important role in proteolysis, the function of nuclear Ub is still obscure. Presumably, ubiquitination of histones affects chromatin structure, but it should be stated at the outset that we do not know how this histone modification influences transcriptional or mitotic processes. W

squander