| 书目名称 | Triple Repeat Diseases of the Nervous Systems |
| 编辑 | Lubov T. Timchenko |
| 视频video | |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | World of Unstable Mutations The book "Triplet Repeat Diseases of the Nervous System" overviews the lat est data on several disorders associated with unstable mutations. This field of re search is progressing extremely fast. The number of polymorphic mutations and diseases caused by these mutations is increasing almost every month. There is a strong interest to molecular bases of triplet repeat disorders. This is explained by growing necessity to develop molecular approaches for cure of these diseases. There fore, the authors of this book describe unstable mutations with the emphasis on molecular pathology. Broad discussion is presented on how polymorphic expan sions cause cell dysfunction. o The first chapter of the book focuses on the molecular pathological pro cesses that originate "unstable" mutations. The authors review several avail able models by which normal "stable" region of DNA become pathogenic and discuss possible mechanisms causing DNA instability. o The other chapters of the book describe inherited diseases associated with different types of unstable mutations. Based on the location of mutation in the disease gene, polymorphic expansions of the nervous system ca |
| 出版日期 | Book 2002 |
| 关键词 | DNA; Nervous System; Pathogene; genes; metabolism; molecular mechanisms; Tree Biology |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4615-0117-6 |
| isbn_softcover | 978-1-4613-4931-0 |
| isbn_ebook | 978-1-4615-0117-6Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 17:22:36
