| 书目名称 | Transporters in Drug Development |
| 副标题 | Discovery, Optimizat |
| 编辑 | Yuichi Sugiyama,Bente Steffansen |
| 视频video | |
| 概述 | Answers key questions in drug development.Written by leaders in the field.Covers both pharmaceutical industry and FDA perspectives |
| 丛书名称 | AAPS Advances in the Pharmaceutical Sciences Series |
| 图书封面 |  |
| 描述 | .Transporters in Drug Development. examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of .in vitro. characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating .in vitro. observed interaction of transporters into .in vivo. relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process. . |
| 出版日期 | Book 2013 |
| 关键词 | AAPS; Development; Drug; Steffansen; Sugiyama; Transporters |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-4614-8229-1 |
| isbn_softcover | 978-1-4939-5206-9 |
| isbn_ebook | 978-1-4614-8229-1Series ISSN 2210-7371 Series E-ISSN 2210-738X |
| issn_series | 2210-7371 |
| copyright | Springer Science+Business Media New York 2013 |
发表于 2025-3-21 18:09:16
