| 书目名称 | Translational Research Methods in Neurodevelopmental Disorders |
| 编辑 | Stéphane Martin,Frédéric Laumonnier |
| 视频video | |
| 概述 | Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts |
| 丛书名称 | Neuromethods |
| 图书封面 |  |
| 描述 | .This volume explores the latest techniques used to study neurodevelopmental diseases (NDD) that range from molecular aspects to integrated research approaches and brain imaging in living rodents. Chapters in this book cover topics such as protocols to deliver shRNA in vitro and in vivo using lentiviral particles to knock-down specific protein expression; experimental procedures to use recombinant fluorescent probes to visualize endogenous proteins at the mammalian synapse; CRISPR/Cas9 toolkit to assess either gain- or loss-of-gene function in brain organoids; detailed protocols to use in vivo manipulations to correct the behavioral phenotypes in cognitive disorder mouse lines; and experimental approaches to genetically engineer macaque models of NDDs and investigate how genetic predisposition may cause neural and functional alterations. In the .Neuromethods. series style, chapters include the kind of detail and key advice from the specialists needed to get successful results inyour laboratory. .Cutting-edge and practical, .Translational Research Methods in Neurodevelopmental Disorders. is a valuable resource for all researchers who want to learn more about this important and devel |
| 出版日期 | Book 2022 |
| 关键词 | Autism Spectrum Disorders; Intellectual Disability; neurotransmitter release assays; Next generation se |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-1-0716-2569-9 |
| isbn_softcover | 978-1-0716-2571-2 |
| isbn_ebook | 978-1-0716-2569-9Series ISSN 0893-2336 Series E-ISSN 1940-6045 |
| issn_series | 0893-2336 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines |
发表于 2025-3-21 17:12:42
