| 书目名称 | The Th2 Type Immune Response in Health and Disease | | 副标题 | From Host Defense an | | 编辑 | William C. Gause,David Artis | | 视频video | | | 概述 | Explores the effects of helminth infection on the immune response.Provides an intellectual framework for identifying potentially new treatments for diseases associated with inflammation.Discusses nove | | 图书封面 |  | | 描述 | .The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the late | | 出版日期 | Book 2016 | | 关键词 | Helminth; Immune response; Parasites; Th2 type immune response; inflammation | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4939-2911-5 | | isbn_softcover | 978-1-4939-4573-3 | | isbn_ebook | 978-1-4939-2911-5 | | copyright | Springer Science+Business Media New York 2016 |
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发表于 2025-3-21 17:17:09
