| 书目名称 | The Structural Basis of Arrestin Functions | | 编辑 | Vsevolod V. Gurevich | | 视频video | | | 概述 | Gives a unique insight of the connection between protein structure and function of arrestin and its broad implications.Discussed are structure-based redesign of signalling proteins paves the way for n | | 图书封面 |  | | 描述 | This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death..Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery..The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospecti | | 出版日期 | Book 2017 | | 关键词 | GPCR; Cell Signalling; Protein Structure; Redesigning; Signalling Proteins | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-57553-7 | | isbn_softcover | 978-3-319-86191-3 | | isbn_ebook | 978-3-319-57553-7 | | copyright | Springer International Publishing AG 2017 |
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发表于 2025-3-21 20:09:57
