| 书目名称 | The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation | | 编辑 | Udo Rüb,Jean Paul G. Vonsattel,Horst-Werner Korf | | 视频video | | | 概述 | Describes the progress made during more than hundred years of neuropathological HD research, the neuropathological hallmarks of HD and their pathogenic and clinical relevance.Explains the potential pa | | 丛书名称 | Advances in Anatomy, Embryology and Cell Biology | | 图书封面 |  | | 描述 | This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed. | | 出版日期 | Book 2015 | | 关键词 | CAG-repeats; Vonsattel HD grading system; chromosome 4p16; 3; neurological disorder; neuronal loss; striat | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-19285-7 | | isbn_softcover | 978-3-319-19284-0 | | isbn_ebook | 978-3-319-19285-7Series ISSN 0301-5556 Series E-ISSN 2192-7065 | | issn_series | 0301-5556 | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
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发表于 2025-3-21 17:51:18
