| 书目名称 | The Human T-Cell Receptor Repertoire and Transplantation |
| 编辑 | Peter J. Elsen |
| 视频video | |
| 丛书名称 | Molecular Biology Intelligence Unit |
| 图书封面 |  |
| 描述 | these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-ch |
| 出版日期 | Book 1995 |
| 关键词 | T cell; T-lymphocytes; antigen; cell lines; complementarity determining region 3; cytotoxicity; genes; graf |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-662-22494-6 |
| isbn_softcover | 978-3-662-22496-0 |
| isbn_ebook | 978-3-662-22494-6Series ISSN 1431-0414 |
| issn_series | 1431-0414 |
| copyright | Springer-Verlag Berlin Heidelberg 1995 |
发表于 2025-3-21 18:27:53
