| 书目名称 | The Epothilones: An Outstanding Family of Anti-Tumor Agents |
| 副标题 | From Soil to the Cli |
| 编辑 | K.- H. Altmann,G. Höfle,K. Prantz |
| 视频video | |
| 概述 | Includes supplementary material: |
| 丛书名称 | Fortschritte der Chemie organischer Naturstoffe‘ Progress in the Chemistry of Organic Natural Produc |
| 图书封面 |  |
| 描述 | Epothilones have received unusual attention over the past ten years. They are novel antitumor drugs which very much like their predecessor paclitaxel (Taxol) act via microtubule stabilization. In comparison to paclitaxel and a number of alternative drugs with a similar mode of bioaction (e.g. laulimalide, eleutherobin, peluroside, discodermolide) the epothilones have significant advantages, above all very high activity in the nanomolar range and low susceptibility towards multidrug resistance. Epothilone B and several derivatives thereof are in phase I-III clinical trials; one of them (ixabepilone, BMS) is already on the market, others are supposed to appear on the market in the near future. All naturally occurring epothilones have been isolated from Sorangium cellulosum; their antitumor action is traced back to the stabilization of microtubules. In consequence, the formation of the mitototic spindle is prohibited and the cell undergoes apoptosis. |
| 出版日期 | Book 2009 |
| 关键词 | Expression; anti-tumour agent; anti-tumour drug; apoptosis; biochemistry; chemistry; epothilone; genetic en |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-211-78207-1 |
| isbn_softcover | 978-3-211-99928-8 |
| isbn_ebook | 978-3-211-78207-1Series ISSN 0071-7886 |
| issn_series | 0071-7886 |
| copyright | Springer-Verlag Vienna 2009 |
发表于 2025-3-21 16:33:28
