Titlebook: Systems Biology of Tumor Microenvironment; Quantitative Modelin Katarzyna A. Rejniak Book 2016 The Editor(s) (if applicable) and The Author

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Image Analysis of the Tumor Microenvironment,to the tumor microenvironment as they are to the tumor itself (Beck AH et al. Sci Transl Med 3(108):108ra113–08ra113, 2011). Digital imaging, or whole slide imaging (WSI), of glass histology slides facilitates a number of value-added competencies which were not previously possible with the tradition

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Hypoxia in Gliomas: Opening Therapeutical Opportunities Using a Mathematical-Based Approach,oxic environment. We focus on gliomas, which are primary brain tumors derived from glial cells, mainly astrocytes and/or oligodendrocytes. A variety of mathematical models, based on ordinary and/or partial differential equations, have been developed both at the micro and macroscopic levels. The aim

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Cell-ECM Interactions in Tumor Invasion,ures and adapting to the surrounding microenvironments. The extracellular matrix, as a crucial component of the tumor microenvironment, provides the mechanical support for the tissue, mediates the cell-microenvironment interactions, and plays a key role in cancer cell invasion. The biomechanics of t

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Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance,nt efforts have been committed to experimentally examine how cellular response to anti-cancer treatments varies based on the environment in which the cells are grown. In vitro studies point to specific conditions in which tumor cells can remain dormant and survive the treatment. In vivo results sugg

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The Tumor Microenvironment as a Barrier to Cancer Nanotherapy,ched clinical application. A major reason is that the large number of parameters available to tune nanotherapy characteristics coupled with the variability in tumor tissue precludes evaluation of complex interactions through experimentation alone. In order to optimize the nanotechnology design and g

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