Titlebook: Systems Biology of Apoptosis; Inna N. Lavrik Book 2013 Springer Science+Business Media New York 2013 Apoptosis.Systems Biology

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ublished many papers on Systems Biology applications to Apop.Systems Biology of Apoptosis. summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular p

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Modeling Formalisms in Systems Biology of Apoptosis, neurodegenerative disorders. Quantitative modeling approaches provided valuable insights into the digital and irreversible nature of apoptosis initiation. In this chapter, we summarize the mathematical formalisms used in systems biology of apoptosis. In addition, we give an overview of apoptosis-re

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Systems Biology of Death Receptor-Induced Apoptosis,tosis can lead to numerous diseases, including autoimmune diseases, neurodegenerative diseases, and cancer. In mammalian cells apoptosis can be induced by intra- or extracellular stimuli. Extracellular stimuli comprise death ligands which lead to death receptor-induced apoptosis, referred to as extr

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Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for A model complexity. A common approach to solve this problem is top-down: Initially, complete models including all possible reactions are generated; they are then iteratively reduced to a more manageable size. The reactions to be simplified at each step are often chosen manually since exploration of t

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Systems Biology of the Mitochondrial Apoptosis Pathway,tochondria are able to initiate apoptosis. The Bcl-2 family proteins are the key regulators of the mitochondria-initiated caspase activation pathway. Activation of caspases is considered one of the most important regulatory steps for apoptosis. Caspase cascades can be initiated or amplified by the r

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Systems Biology of Cell Death in Hepatocytes,nals. To obtain insights into the mechanistic interplay of these signals and to define new therapeutic strategies, the combination of experimental data and mathematical modeling is a promising systems biological approach. Here, we review recent results in death receptor-mediated hepatocyte apoptosis

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Understanding Different Types of Cell Death Using Systems Biology, determine many cell events in multicellular and unicellular organisms. Understanding the principles of cell fate decisions is crucial for the studies of some tissue functioning (such as gut epithelium) and for the comprehension of tumour development, for which the tightly regulated mechanism of bal

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