Titlebook: Systemic Lupus Erythematosus; Clinical and Experim Josef S. Smolen,Christoph C. Zielinski Book 1987 Springer-Verlag Berlin Heidelberg 1987

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Relevance of the Murine Models of Systemic Lupus Erythematosus to Human Diseaseevents culminating in autoantibody production and clinical disease manifestations. The precise derangements and interactions of these various factors have been the focus for considerable research in humans and also in the murine lupus models. These lupus-prone mice spontaneoulsy develop an illness w

disciplined

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Complement and Complement Deficienciesmmune complexes. On the other hand, in some individuals there is a lack of C function due to the absence of a particular component of the system. This is not due to consumption but rather to a hereditary deficiency in the synthesis of the component.

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The Role of Lymphokines in the Pathogenesis of Systemic Lupus Erythematosusroduced because the first mediators described were lymphocyte products that inhibited the motility of macrophages and therefore were true “kines” [11, 21]. More recently it was shown that factors similar to lymphokines are also produced by nonlymphocytic cells such as macrophages, fibroblasts, kerat

confide

Clinical and Serologic Features: Incidence and Diagnostic Approachts pathogenetic aspects as well as the spectrum of its clinical manifestations and a variety of indicators of disease activity have become increasingly known over the past decades. In conjunction with improved diagnostic modalities, this knowledge has lately made possible (a) earlier recognition, (b

colloquial

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APO

Neurological Manifestationss peripheral nerves and muscles [1]. Depending on the type and extent of the lesions and on different combinations located throughout the nervous system, they present a great variety of neurological symptoms and syndromes. This led Dubois [28] to state that nervous system SLE has replaced neurosyphi

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Book 1987 recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted