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Titlebook: Systemic Lupus Erythematosus; Clinical and Experim Josef S. Smolen,Christoph C. Zielinski Book 1987 Springer-Verlag Berlin Heidelberg 1987

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h had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has
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ANA Subsets in Systemic Lupus Erythematosus ANA as well as antibodies to the two forms of DNA [native or double-stranded (ds) and denatured or single-stranded (ss)] will not be discussed in this chapter as they have been adequately described in other publications [1, 2].
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Description of Systemic Lupus Erythematosus: A Historical Perspectiverance — was named by Pierre Louis Cazanave “lupus [latin .] erythematosus” in 1851 [2]. Although the term “lupus” was not confined to a single disorder at that time [3], the peculiarity of the skin lesion was fully recognized, resulting in a variety of descriptive terms (e.g., “butterfly rash” [4])
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Genetic Aspects of Murine Lupusesemble those of patients with systemic lupus erythematosus and, to some extent, Sjögren’s syndrome, rheumatoid arthritis, and other autoimmune diseases. These mice have provided substantial insights into the bases for human disease. One conclusion of the mouse studies is that there are critical gen
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