| 书目名称 | Synthesis and Vaccine Evaluation of the Tumor Associated Carbohydrate Antigen RM2 from Prostate Canc |
| 编辑 | Hong-Yang Chuang |
| 视频video | |
| 概述 | Nominated by National Taiwan University as an outstanding Ph.D. thesis.Introduces the synthesis of RM2 antigen using the [1+2+3] one-pot sequential strategy.Presents the preparation of vaccine candida |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | .This thesis focuses on the synthesis and vaccine evaluation of the prostate tumor- associated carbohydrate antigen RM2. The author first presents the use of the [1+2+3] one-pot sequential strategy to successfully synthesise the RM2 antigen and its analogues as single stereoisomers in every glycosylation step, producing good yields and stereoselectivity. He then introduces the conjugation of the synthetic RM2 antigen to the carrier protein CRM197 in an average number of 1–10 to create the prostate cancer vaccine candidate, which is combined with α-galactosylceramide C1, its analogue C34, or Alu. The results of the vaccination studies in mice are also described and indicate that the strongest anti-RM2 antigen titer is exhibited when one molecule of diphtheria toxin (DT) is conjugated with an average of 4.7 molecules of RM2 antigen (DT-RM4.7) and adjuvanted with the glycolipid C34. More importantly, the induced mouse antibodies mediate the effective complement-dependent cytotoxicity (CDC) against the prostate cancer cell line LNCap. The study presented in this thesis is the first ever to successfully synthesize this complex glycan molecule. Owing to the steric hindrance of the adjace |
| 出版日期 | Book 2015 |
| 关键词 | Cancer-associated antigen; Carbohydrate-based vaccine; Disialogangliosides; Glycolipid adjuvant; Immunol |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-662-46848-7 |
| isbn_softcover | 978-3-662-52634-7 |
| isbn_ebook | 978-3-662-46848-7Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer-Verlag Berlin Heidelberg 2015 |
发表于 2025-3-21 19:33:53
