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Titlebook: Stunning, Hibernation, and Calcium in Myocardial Ischemia and Reperfusion; Lionel H. Opie (Professor of Medicine, Visiting Pr Book 1992 Kl

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Pathogenetic Role for Calcium in Stunning?, it suggests a possible common pathway for cell injury by a variety of specific agents. A provocative feature of the formulation is the idea that the crucial lesion in stunning occurs at the level of the contractile proteins, rather than more proximally.
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Role of Adenosine in the Treatment of Myocardial Stunningincrease in the total myocardial ATP stores. Adenosine may be a useful pharmacologic strategy in the prevention and treatment of ventricular dysfunction following episodes of regional or global ischemia, although further studies are needed to clarify the precise cellular mechanisms involved.
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Clinical Relevance of Myocardial “Stunning” ischemia, or hibernation (i.e., chronic ischemia). This differential diagnosis requires the simultaneous measurement of regional myocardial function and flow, which thus far has not been generally possible. Despite these limitations, however, numerous clinical observations suggest that stunning doe
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