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Titlebook: Structure and Function of the Aspartic Proteinases; Genetics, Structures Ben M. Dunn Book 1991 The Editor(s) (if applicable) and The Author

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Book 1991lifornia. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first t
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A Highly Informative Polymorphism of the Pepsinogen C Gene Detected by Polymerase Chain Reactionriction fragment length polymorphism by Southern blot analysis of genomic DNA with a PGC cDNA clone. This RFLP involved a 100 bp insertion or deletion of intron sequence located between exons 7 and 8. Analysis of families segregating for this polymorphism indicated that there is a single human PGC gene located on the short arm of chromosome 6.
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Effects of Viscosity and Solvent Deuterium Identify Multiple Partially Rate-Limiting Steps in the Ki pepsin. Also, isotope effects have been reported that are difficult to interpret within accepted kinetic mechanisms. Solvent deuterium isotope effect studies were undertaken to show the extent to which proton transfer affects the observed reaction rate and to determine at which step in the reaction proton transfer(s) occur.
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