Titlebook: Structure and Function in Excitable Cells; Donald C. Chang,Ichiji Tasaki,H. Richard Leuchtag Book 1983 Plenum Press, New York 1983 biochem

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AGONY

Noise, Impedance, and Single-Channel Currentse ionic currents that make up the action potential. Second, we want to understand how the channels actually work at the molecular level. When we achieve this we can answer the following questions. What channel properties are responsible for macroscopic properties of membranes (threshold, action pote

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HALL

Ion-Selectivity and ”Gating” Properties of the Conductance Pathways in Squid Axones of the conductance pathways of the nerve cell, and (2) to discuss how these findings can be used to differentiate various hypotheses of “channel” structure, based either on the traditional membrane view or an alternative view, the membrane-cortex model.

LEER

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Axolemma—Ectoplasm Complex and Mechanical Responses of the Axon Membranes (Metuzals and Izzard, 1969; Metuzals and Tasaki, 1978; Hodge and Adelman, 1980). An extensive destruction of this layer by intracellular perfusion with a solution containing chaotropic anions or proteolytic enzymes is known to lead to a loss of excitability. Therefore, we believe that this layer,

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History of the Physical Chemistry of Charged Membranessk in this chapter must necessarily be more limited as indicated by the title “Charged Membranes.”* Seen in retrospect, the primary problems and speculations were concerned with the riddle of many life processes. The search began with experiments on frog muscle contractions by Galvani about 1780 (Fi

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overall objective is to further the search for a better understanding of the mechanism of excitation on a structural and physicochemical basis. The chapters are written by active investigators from a variety of disciplines, repre­ senting many different points of view. Their complementary fields of