| 书目名称 | Structural and Biochemical Characterization of the YaxAB Pore-forming Toxin from Yersinia Enterocoli |
| 编辑 | Bastian Bräuning |
| 视频video | |
| 概述 | Nominated as an outstanding Ph.D. thesis by the Technische Universitat Munchen, Garching, Germany.Serves as a comprehensive case study of a difficult target protein.Focuses on cutting-edge methodology |
| 丛书名称 | Springer Theses |
| 图书封面 |  |
| 描述 | This book discusses the decoding of the lytic mechanism of an α-helical pore-forming toxin, YaxAB, composed of two different subunits. Pore-forming toxins (PFTs) are among the most common bacterial toxins. They are produced by a variety of pathogens, which infect a wide range of organisms including plants, insects and humans. Yet the maturation of these particles and the structural changes required for pore formation are still poorly understood for many PFT families.. .Using a diverse panel of biochemical and structural techniques, including X-ray crystallography and cryo-electron microscopy, Dr. Bräuning and colleagues have succeeded in identifying the mechanistic contributions of the two toxin components and elucidating the lytic state of the pore complex. The results of this thesis on the YaxAB system are applicable to orthologues from agriculturally relevant insect pathogens, and offer valuable structural and mechanistic insights to inform future bioengineering efforts. . |
| 出版日期 | Book 2019 |
| 关键词 | PFT; Virulence Factors; Enterobacteriaceae; Insecticidal Toxin; Nanopore Engineering; Cryo-electron Micro |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-29439-7 |
| isbn_softcover | 978-3-030-29441-0 |
| isbn_ebook | 978-3-030-29439-7Series ISSN 2190-5053 Series E-ISSN 2190-5061 |
| issn_series | 2190-5053 |
| copyright | Springer Nature Switzerland AG 2019 |
发表于 2025-3-21 18:12:37
