Titlebook: Structural Genomics and Drug Discovery; Methods and Protocol Wayne F. Anderson Book 2014 Springer Science+Business Media, New York 2014 Str

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Salvage of Failed Protein Targets by Reductive Alkylation,ates were obtained and the impact of reductive alkylation of lysine residues was assessed. Reductive methylation tends to be more efficient and produces the most alkylated protein structures. Structures of methylated proteins typically have higher resolution limits. A number of well-ordered alkylate

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Structure Determination, Refinement, and Validation,PDB) also needs to be know how to evaluate structural models, understand how they are related to the experimental data and be able to utilize computer graphics programs to look at the electron density distribution together with the model.

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1064-3745 ation advice from the experts.Includes supplementary materia.Structural Genomics and Drug Discovery: Methods and Protocols focuses .on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that

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Structural Genomics of Human Proteins,amilies; to understand the structural basis of disease and genetic variation; and to determine the structures of human integral membrane proteins. The overarching theme is to advance the understanding of human health and to provide a structural platform to aid in the development of therapeutics. A d

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Target Selection for Structural Genomics of Infectious Diseases,ases. Protocols often combine computational approaches for mining information in public databases or for checking whether the protein has already been targeted for structure determination, with manual strategies that examine the literature for information on the biological role of the protein or the

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