Titlebook: Stroke Genetics; Pankaj Sharma,James F. Meschia Textbook 2024Latest edition Mayo Clinic 2024 CADASIL.Fabry.GWAS.MELAS.cerebral hemorrhage

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White Matter Disease,been linked to risk of ischemic and hemorrhagic strokes. This subtype of WM disease, also known as WM lesions (WMLs), WM hyperintensity (WMH), or leukoaraiosis, has been described in the context of epidemiological studies of aging adults with subtle, but progressive, signs of neurological dysfunctio

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Genetics of Small Vessel Disease, that feature the same CSVD manifestations and their causal genes, such as . and collagen genes. Lastly, we review the data that support the involvement of the genes for familial disease in sporadic CSVD manifestations. From the combination of these perspectives, we can detect the genes and the corr

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Genetics of Carotid Atherosclerosis,ts response to therapy. This chapter will focus on carotid atherosclerotic disease and its relationship to ischemic stroke. Other chapters in this volume will address other forms of carotid pathology related to stroke, such as carotid dissection.

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Genetics of Cervical Artery Dissection,om a large international effort gathering samples from over 2000 CeAD patients, identified a common intronic variant in . to be significantly associated with CeAD risk. Interestingly, the same variant has also shown association with migraine, fibromuscular dysplasia, coronary artery dissection, hype

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Cerebral Venous Thrombosis: Genetic Aspects,e genome-wide case control study identified a locus associated with an increased risk of CVT. Routine screening of thrombophilia with the aim of decreasing the risk of death or disability in CVT patients is not recommended. Thrombophilia screening may be performed in patients with high pre-test prob

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Introduction,paresis, a locked-in syndrome, reversal of personality, and, ultimately, death..In itself such a disease would be undesirable, but the common frequency of stroke makes it all the more feared. Stroke is the fourth commonest cause of death in the West, yet this simple statement belies the heavy toll i

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