Titlebook: Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Co; Sebastien Gagneux Book 2017 The Edit

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Mathematical Models for the Epidemiology and Evolution of ,,ter with a discussion of the practical implications of modelling – particularly modelling strain diversity – for controlling the spread of tuberculosis, and future directions for research in this area.

Phenothiazines

反复拉紧

The Nature and Evolution of Genomic Diversity in the , Complex, we discuss the origins and the evolutionary forces shaping the genomic diversity of the human-adapted MTBC. Advances in whole-genome sequencing have brought invaluable insights into the macro-evolution of the MTBC, and the biogeographical distribution of the different MTBC lineages, the phylogeneti

Influx

BROOK

excursion

演讲

Biological and Epidemiological Consequences of MTBC Diversity,ns and bacterial virulence determine the extent and form of human disease. MTBC virulence is a composite of different clinical phenotypes such as transmission rate and disease severity among others. Clinical phenotypes are also influenced by cellular and immunological phenotypes. MTBC phenotypes are

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HARD

, Complex Members Adapted to Wild and Domestic Animals,nd those that possess the ability to propagate and transmit in a variety of wild and domesticated animals. Since the initial description of the bovine tubercle bacillus, now known as ., by Theobald Smith in the late 1800’s, isolates originating from a wide range of animal hosts have been identified

exostosis

Evolution and Strain Variation in BCG,BCG to vaccine production laboratories around the world, it was only a few decades before different BCG producers recognized that there were variants of BCG, likely due to different passaging conditions in the different laboratories. This ultimately led to the lyophilization of stable BCG products i