Titlebook: Stem Cells, Pre-neoplasia, and Early Cancer of the Upper Gastrointestinal Tract; Marnix Jansen,Nicholas A. Wright Book 2016 The Editor(s)

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Endoscopic Treatment of Early Barrett’s Neoplasia: Expanding Indications, New Challengesta suggest radiofrequency ablation of low-grade intraepithelial neoplasia when confirmed by an expert pathologist. Endoscopic therapy of high-grade intraepithelial neoplasia and mucosal Barrett’s adenocarcinoma consists of two steps: first endoscopic resection of all visible lesions, and second abla

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Definition, Derivation, and Diagnosis of Barrett’s Esophagus: Pathological Perspectivesdefining features and the diagnosis of columnar-lined esophagus (CLO) are still embroiled with controversy and uncertainty. For pathologists, these controversies are notorious. The disease has been defined by the pathological demonstration of “specialized intestinal metaplasia” and yet there is comp

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Genomics of Esophageal Cancer and Biomarkers for Early Detectionhas led to better understanding of its genomic landscape. More specifically, analysis of its pathogenesis at the genetic level has uncovered the involvement of a number of tumor suppressor genes, cell cycle regulators, and receptor tyrosine kinases. Due to its poor prognosis, the development of clin

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